small-molecule inhibitors chir99021 Search Results


small-molecule inhibitors chir99021  (Axon Medchem LLC)
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molecule inhibitors  (Selleck Chemicals)
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molecule inhibitor chir99021  (Tocris)
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molecule inhibitor chir99021  (Exosome Diagnostics)
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small-molecule inhibitors pd0325901  (Axon Medchem LLC)
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glycogen synthase kinase 3 gsk3 inhibitor chir99021  (Biogems International)
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chir 99021  (Bio-Techne corporation)
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chir99021  (STEMCELL Technologies Inc)
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dbz  (Bio-Techne corporation)
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small molecule inhibitors iwp2  (Selleck Chemicals)
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Selleck Chemicals small molecule inhibitors iwp2
Wnt inhibition greatly improves the development of SCNT embryos. (a) Comparison of Wnt-related genes in differential gene expression profiles of the ICM of IVF and SCNT blastocysts. The genes marked are Wnt antagonists or activators. (b) TCF/Lef: H2B-GFP IVF (left) and SCNT (right) embryos at late E4.5 stained for GFP, Oct4, Gata6 and DAPI. Scale bar, 20 μm. (c) Percentage of GFP-positive cells in the EPI of IVF and SCNT embryos. (d) Percentage of rosette-like SCNT embryos generated with no treatment, Wnt activator CHIR treatment and Wnt inhibitor <t>IWP2</t> treatment. (e) Comparison of pluripotent marker gene expression among the IVF-, SCNT- and Wnti-treated SCNT embryos. (f) Absolute value comparison of the relative expression of markers in (d) to late-E4.5 IVF EPI between groups of IVF-, SCNT- and Wnti-SCNT embryos. P -values were determined using the Wilcoxon signed-rank test. (g) GSEA of specific genes expressed in naïve and primed ESCs between the late-E4.5 EPI of untreated and Wnti-SCNT embryos. NES, normalized enrichment score. (h) PCA comparison of gene expression profiles among the late-E4.5 EPI of IVF-, SCNT- and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. Published transcriptome data of stem cell lines were obtained from GSE145727. (i) Hierarchical clustering analysis of the late-E4.5 EPI of IVF, untreated and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. (j) PCA plot of E3.5 ICM, E5.5 EPI, E6.5 EPI, late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos based on the H3K27me3 levels. (k) Heat map showing the H3K27me3 levels for the naïve and primed markers between late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos. For (c) and (d), P -values were determined using the unpaired two-tailed t -test; error bars and means ± SD are shown for n ≥ 3 experiments.
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stemolecule chir99021  (AMS Biotechnology)
96
AMS Biotechnology stemolecule chir99021
Wnt inhibition greatly improves the development of SCNT embryos. (a) Comparison of Wnt-related genes in differential gene expression profiles of the ICM of IVF and SCNT blastocysts. The genes marked are Wnt antagonists or activators. (b) TCF/Lef: H2B-GFP IVF (left) and SCNT (right) embryos at late E4.5 stained for GFP, Oct4, Gata6 and DAPI. Scale bar, 20 μm. (c) Percentage of GFP-positive cells in the EPI of IVF and SCNT embryos. (d) Percentage of rosette-like SCNT embryos generated with no treatment, Wnt activator CHIR treatment and Wnt inhibitor <t>IWP2</t> treatment. (e) Comparison of pluripotent marker gene expression among the IVF-, SCNT- and Wnti-treated SCNT embryos. (f) Absolute value comparison of the relative expression of markers in (d) to late-E4.5 IVF EPI between groups of IVF-, SCNT- and Wnti-SCNT embryos. P -values were determined using the Wilcoxon signed-rank test. (g) GSEA of specific genes expressed in naïve and primed ESCs between the late-E4.5 EPI of untreated and Wnti-SCNT embryos. NES, normalized enrichment score. (h) PCA comparison of gene expression profiles among the late-E4.5 EPI of IVF-, SCNT- and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. Published transcriptome data of stem cell lines were obtained from GSE145727. (i) Hierarchical clustering analysis of the late-E4.5 EPI of IVF, untreated and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. (j) PCA plot of E3.5 ICM, E5.5 EPI, E6.5 EPI, late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos based on the H3K27me3 levels. (k) Heat map showing the H3K27me3 levels for the naïve and primed markers between late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos. For (c) and (d), P -values were determined using the unpaired two-tailed t -test; error bars and means ± SD are shown for n ≥ 3 experiments.
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iwr-1-endo  (STEMCELL Technologies Inc)
90
STEMCELL Technologies Inc iwr-1-endo
Wnt inhibition greatly improves the development of SCNT embryos. (a) Comparison of Wnt-related genes in differential gene expression profiles of the ICM of IVF and SCNT blastocysts. The genes marked are Wnt antagonists or activators. (b) TCF/Lef: H2B-GFP IVF (left) and SCNT (right) embryos at late E4.5 stained for GFP, Oct4, Gata6 and DAPI. Scale bar, 20 μm. (c) Percentage of GFP-positive cells in the EPI of IVF and SCNT embryos. (d) Percentage of rosette-like SCNT embryos generated with no treatment, Wnt activator CHIR treatment and Wnt inhibitor <t>IWP2</t> treatment. (e) Comparison of pluripotent marker gene expression among the IVF-, SCNT- and Wnti-treated SCNT embryos. (f) Absolute value comparison of the relative expression of markers in (d) to late-E4.5 IVF EPI between groups of IVF-, SCNT- and Wnti-SCNT embryos. P -values were determined using the Wilcoxon signed-rank test. (g) GSEA of specific genes expressed in naïve and primed ESCs between the late-E4.5 EPI of untreated and Wnti-SCNT embryos. NES, normalized enrichment score. (h) PCA comparison of gene expression profiles among the late-E4.5 EPI of IVF-, SCNT- and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. Published transcriptome data of stem cell lines were obtained from GSE145727. (i) Hierarchical clustering analysis of the late-E4.5 EPI of IVF, untreated and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. (j) PCA plot of E3.5 ICM, E5.5 EPI, E6.5 EPI, late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos based on the H3K27me3 levels. (k) Heat map showing the H3K27me3 levels for the naïve and primed markers between late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos. For (c) and (d), P -values were determined using the unpaired two-tailed t -test; error bars and means ± SD are shown for n ≥ 3 experiments.
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Image Search Results


Wnt inhibition greatly improves the development of SCNT embryos. (a) Comparison of Wnt-related genes in differential gene expression profiles of the ICM of IVF and SCNT blastocysts. The genes marked are Wnt antagonists or activators. (b) TCF/Lef: H2B-GFP IVF (left) and SCNT (right) embryos at late E4.5 stained for GFP, Oct4, Gata6 and DAPI. Scale bar, 20 μm. (c) Percentage of GFP-positive cells in the EPI of IVF and SCNT embryos. (d) Percentage of rosette-like SCNT embryos generated with no treatment, Wnt activator CHIR treatment and Wnt inhibitor IWP2 treatment. (e) Comparison of pluripotent marker gene expression among the IVF-, SCNT- and Wnti-treated SCNT embryos. (f) Absolute value comparison of the relative expression of markers in (d) to late-E4.5 IVF EPI between groups of IVF-, SCNT- and Wnti-SCNT embryos. P -values were determined using the Wilcoxon signed-rank test. (g) GSEA of specific genes expressed in naïve and primed ESCs between the late-E4.5 EPI of untreated and Wnti-SCNT embryos. NES, normalized enrichment score. (h) PCA comparison of gene expression profiles among the late-E4.5 EPI of IVF-, SCNT- and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. Published transcriptome data of stem cell lines were obtained from GSE145727. (i) Hierarchical clustering analysis of the late-E4.5 EPI of IVF, untreated and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. (j) PCA plot of E3.5 ICM, E5.5 EPI, E6.5 EPI, late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos based on the H3K27me3 levels. (k) Heat map showing the H3K27me3 levels for the naïve and primed markers between late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos. For (c) and (d), P -values were determined using the unpaired two-tailed t -test; error bars and means ± SD are shown for n ≥ 3 experiments.

Journal: National Science Review

Article Title: Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos

doi: 10.1093/nsr/nwad173

Figure Lengend Snippet: Wnt inhibition greatly improves the development of SCNT embryos. (a) Comparison of Wnt-related genes in differential gene expression profiles of the ICM of IVF and SCNT blastocysts. The genes marked are Wnt antagonists or activators. (b) TCF/Lef: H2B-GFP IVF (left) and SCNT (right) embryos at late E4.5 stained for GFP, Oct4, Gata6 and DAPI. Scale bar, 20 μm. (c) Percentage of GFP-positive cells in the EPI of IVF and SCNT embryos. (d) Percentage of rosette-like SCNT embryos generated with no treatment, Wnt activator CHIR treatment and Wnt inhibitor IWP2 treatment. (e) Comparison of pluripotent marker gene expression among the IVF-, SCNT- and Wnti-treated SCNT embryos. (f) Absolute value comparison of the relative expression of markers in (d) to late-E4.5 IVF EPI between groups of IVF-, SCNT- and Wnti-SCNT embryos. P -values were determined using the Wilcoxon signed-rank test. (g) GSEA of specific genes expressed in naïve and primed ESCs between the late-E4.5 EPI of untreated and Wnti-SCNT embryos. NES, normalized enrichment score. (h) PCA comparison of gene expression profiles among the late-E4.5 EPI of IVF-, SCNT- and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. Published transcriptome data of stem cell lines were obtained from GSE145727. (i) Hierarchical clustering analysis of the late-E4.5 EPI of IVF, untreated and Wnti-SCNT embryos, naïve ESCs, primed ESCs and RSCs. (j) PCA plot of E3.5 ICM, E5.5 EPI, E6.5 EPI, late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos based on the H3K27me3 levels. (k) Heat map showing the H3K27me3 levels for the naïve and primed markers between late-E4.5 EPI of IVF, SCNT and Wnti-SCNT embryos. For (c) and (d), P -values were determined using the unpaired two-tailed t -test; error bars and means ± SD are shown for n ≥ 3 experiments.

Article Snippet: Small-molecule inhibitors IWP2 (Selleck, 686770-61-6), IWR1-endo (Selleck, 1127442-82-3) and Wnt activator CHIR99021 (Sigma, SML1046) were applied to inhibit or activate the canonical Wnt/β-catenin signaling pathway.

Techniques: Inhibition, Comparison, Gene Expression, Staining, Generated, Marker, Expressing, Two Tailed Test